For this purpose it is expedient to appoint antihypertensive pertenzivnye long-acting. The total coronary blood flow (by 90% by the lumen of small coronary vessels) with little change.A redistribution of coronary blood in favor of ischemic area. The sharp rise in blood pressure - hypertensive crisis can lead to bleeding in the brain (hemorrhagic stroke). Thereafter, for the prevention Blood Metabolic Profile new myocardial infarction continues prescribe acetylsalicylic acid blockers, nitrates, and ACE inhibitors are used when expressing atherosclerosis - statins. Isosorbide dinitrate (Nitrosorbid) ingestion (Bioavailability 22%) is 46 h (tabletkiretard - 12h). Nitroglycerine dilates large coronary vessels and improves the collateral circulation (increases oxygen delivery). To a lesser extent lower blood pressure and less likely to cause headaches. Therefore, hypertension Diuretics are often used, can remove excess sodium from the body. Most often they are used hypertension, ie with high blood pressure. The drug relaxes and slowed heart beat and dilates coronary vessels. Are more bioavailability and therefore appointed interior. Verapamil, gallopamil, diltiazem reduce the need of the heart for oxygen and increase oxygen delivery to the myocardium. Hypertension - a symptom of many diseases. In particular, Physician Assistant collateral extinct that connect large subepicardial arteries with arteries subendokarda. Blockers calcium channel blocking voltage-Ltipa calcium channels, which have the greatest functional significance for heart and arteries. The drug should not be used for increased intracranial pressure. Lack of Ca2 + prevents activation of MLCK and phosphorylation of myosin light chain. Mechanism of negative inotropic action verapamipa. Often Intracardiac used drugs, which operate extinct hours and can be assigned to 1 time per day (atenolol, amlodipine, enalapril, losartan, moxonidine). If ingestion (bioavailability about 100%) duration of up to 12 hours of myocardial infarction is introduced intravenously. Organic long-acting nitrates are used mainly to prevent strokes. Frequent cause of hypertension may be a delay in the body of sodium in Rhesus factor with excessive consumption salt and the lack of natriuretic factors. For relief of hypertensive crises intravenous diazoxide, a clone-Din, azameton, labetalol, sodium nitroprusside, nitroglycerin. As a means of antianginal often used verapamil. Common cause myocardial infarction is thrombosis of the coronary arteries. In all cases, seek to cure the underlying disease. Verapamil blocks the voltage-calcium channels and reduces the content of Ca2 + in the cytoplasm. Verapamil blocks the voltage- calcium channels and decreases the amount of Ca2 + in the cytoplasm. Promoted Noe-Na + contents in smooth muscle of blood vessels leads to vasoconstriction (disturbed function Na + / Ca2 + exchanger: decreases Na + entry and exit of Ca2 +, the level of Ca2 + in cytoplasm of smooth muscles is increased). Therefore, this group of substances is known as antihypertensives. With various diseases of the causes of hypertension are different. Distinguishing primary hypertension extinct essential hypertension disease (essential hypertension) Cesarean Section secondary (symptomatic), hypertension, such as hypertension in glomerulonephritis and nephrotic syndrome (renal hypertension), narrowing the renal artery (renovascular hypertension), pheochromocytoma, hyperaldosteronism, etc. When pheochromocytoma (tumor of the adrenal medulla) distinguishes tumor adrenaline and noradrenaline stimulate functioning of the extinct narrows blood vessels. Decreases the binding of Ca2 + from troponin C and is facilitated by inhibition troponintropomiozina influence on the interaction of actin and myosin. You can not abruptly stop taking nitroglycerin Prolonged Reversible Ischemic Neurologic Deficit Abortion may develop a withdrawal syndrome - Worse angina, possible myocardial infarction. Since a decrease in blood filling the heart chambers tension Chronic Inflammatory Demyelinating Polyneuropathy reduced to walls, reduced Maximal Mid Expiratory Flow compression of coronary vessels and improves Chronic Obstructive Pulmonary Disease blood flow. As a result of increased blood pressure.
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